GSK1059615 749944 NSC 664704

NSC 664704

10-pentaene-2

Each library contains 2 or 5 mg of listed compounds in that category in separated vials in DMSO at the concentration of 10 mM or in solid format

Smiles: CC1=CC(OCCNC2CCN(CC2)C(=O)C2C=CN=CC=2)=C(C)C=C1

1956356-56-1

GSK1059615 749944 NSC 664704GSK1059615 is a phosphoinositide 3 kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl 2 family of proteins. PIK3, an enzyme often overexpressed in