Pemetrexed (disodium) ium (Chloride) S3I-201 significantly reduces viable cell

S3I-201 significantly reduces viable cell numbers and inhibits growth of transformed mouse fibroblasts NIH 3T3/v-Src and breast carcinoma cell lines (MDA-MB-231

InChi: InChI=1S/C21H23Cl2N5O/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17/h1-6

2015 Nov-Dec

Kleinhenz JM

CAS Number: 1639042-08-2

Pemetrexed (disodium) ium (Chloride) S3I-201 significantly reduces viable cellPemtrexed disodium is the disodium salt of a synthetic pyrimidine based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2' deoxyuridine 5' monophosphate (dUMP) to 2' deoxythymidine 5' monophosphate (dTMP), an essential precursor in DNA synthesis. Product information CAS Number: 150399 23 8 Molecular Weight: 471. 37 Formula: C20H19N5Na2O6 Synonym: LY231514 disodium Alimta disodium LY