Atovaquone yvitamin D3 in mice induces a rapid

in mice induces a rapid Akt phosphorylation readily detectable in lung lysates

is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation

Chemical Name: methyl 3-[4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl]-5-[(4-carbamimidoylpiperazin-1-yl)methyl]benzoate trihydrochloride

InChi: InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7

Smiles: CC(C)CN1C=NC2=C(N)N=C3C=CC=CC3=C12

Atovaquone yvitamin D3 in mice induces a rapidAtovaquone is a synthetic hydroxynaphthoquinone with antiprotozoal activity that has antimicrobial activity and is being used in antimalarial protocols. Atovoquone blocks the mitochondrial electron transport at complex III of the respiratory chain of protozoa, thereby inhibiting pyrimidine synthesis, preventing DNA synthesis and leading to protozoal death. It is an analog of protozoan mitochondrial protein ubiquinone, and acts by inhibiting the