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Prog Neuropsychopharmacol Biol Psychiatry 35(3):74459

(Source 6) Glutathione synthase deficiency is a rare disorder, affecting less than one in 100,000 people

This transporter has similarities to the cystic fibrosis transmembrane conductance regulator (CFTR), which has been shown to be responsible for GSH flux from lung airway epithelial cells (Kogan et al , 2003), suggesting that ABC transporters might function in the transport of glutathione in mammalian cells

Glutathione anabolism is regulated by the transcription factor Nrf2 and is an important antioxidant metabolic pathway

Smokers need 35 mg more vitamin C per day than non-smokers