CUN25391 - a tubulin inhibitor.CAS# 105925-39-1 Catalog No.:M6986-10 10074-G5 binds in a cavity

10074-G5 binds in a cavity that is created by a kink (Asp379-Ile381) in the N-terminus of an induced helical domain (Leu370–Arg378)

Nocodazole enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies

InChiKey: HZCOFZVJMJRKIB-UHFFFAOYSA-N

release an amount of LDH (12

PubMed PMID: 9218617

CUN25391 - a tubulin inhibitor.CAS# 105925-39-1 Catalog No.:M6986-10 10074-G5 binds in a cavityCUN25391, a tubulin inhibitor., CAS No. 105925 39 1, also known as Tubulin inhibitor 6 or iHAP1 (Compound 14b in literature 1) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. CUN25391 inhibits tubulin polymerization with an IC50 of 0. 87 M. CUN25391 has CAS#105925 39 1, no formal name. For the convenience of scientific communication, we named it as CUN25391(combined from Inchi key plus CAS#) according to Hodoodo Chemical