Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 45 Suppl 4

45 Suppl 4

by activating a certain family of voltage-gated potassium channels in the brain

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Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction

Melania Guerrero Hue

Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 45 Suppl 4Crizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8