CYLD(Phospho-Ser418) Rabbit Polyclonal Antibody, 20ul Multiplex Immunoassays HIF-1 functions as a master

HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes

Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder

suggesting that it may be involved in extracellular matrix adhesion

Does not have core 4 O-glycan or I-branching enzyme activity

by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex

CYLD(Phospho-Ser418) Rabbit Polyclonal Antibody, 20ul Multiplex Immunoassays HIF-1 functions as a masterThis gene is encodes a cytoplasmic protein with three cytoskeletal associated protein glycine conserved (CAP GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis multiple familial trichoepithelioma and Brooke Spiegler syndrome. Alternate transcriptional splice variants encoding different isoforms have been characterized.