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3.2.1 Inhibiting Tumour Cell Growth and Increasing Apoptosis 3.2.1.1 In Vitro Studies The plant flavonoid hesperidin (HES) is a natural product with obvious anti-tumor effects and is widely present in citrus fruits, piperine (PIP), and bee venom (BV) extracted from black pepper ( Piper nigrum L.) and long pepper ( Piper longum L.) (Park et al., 2011

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