WZ4003 299 PubMed PMID: 17785584
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WZ4003 299 PubMed PMID: 17785584WZ4003 is a selective inhibitors of the LKB1 tumour suppressor activated NUAK kinases. WZ4003 inhibits both NUAK isoforms (IC50 for NUAK1 is 20 nM and for NUAK2 is 100 nM). WZ4003 displays extreme selectivity and do not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members. In all cell lines tested, WZ4003 inhibits the phosphorylation of the only well characterized substrate, MYPT1 (myosin phosphate
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