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Dofequidar fumarate - CAS# 153653-30-6 K-779 Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1

Dofequidar fumarate - CAS# 153653-30-6 K-779 Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1

Name: Dofequidar fumarate - CAS# 153653-30-6 K-779 Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1
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Dofequidar fumarate - CAS# 153653-30-6 K-779 Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1Dofequidar(MS 209) is a novel quinoline compound, which can reverse P glycoprotein (P gp) mediated MDR. IC50 value: Target: P gpin vitro: MS 209 at 3 microM effectively overcame docetaxel resistance in MDR cancer cells, and this concentration was achieved in blood plasma for > 7 h without serious toxicity . MS 209 restored chemosensitivity of SBC 3 ADM cells to VP 16, ADM, and VCR in a dose dependent manner in vitro . MS 209 strongly reversed drug

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Description

Smiles: O=C1C(Cl)=C(C(=O)N1C1C=C(Cl)C(Cl)=CC=1)N1CCOCC1

¹⁹]nonadeca-2(7)

consistent with the colocalization of norepinephrine and neuropeptide Y

InChiKey: RHUJMHOIQBDFQR-UHFFFAOYSA-N

GSK-429286A

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