SD70 - Histone Demethylase JMJD2 Inhibitor. CAS# 332173-89-4 6057 InChiKey: ZKXZLIFRWWKZRY-KRWDZBQOSA-N

InChiKey: ZKXZLIFRWWKZRY-KRWDZBQOSA-N

CAS Number: 1271738-62-5

SGC0946 was delivered via subcutaneously implanted mini-osmotic pumps capable of continuous infusion (drug load is ~50 mg/ml solution) for a period of 7 days in animal models

(2016) Nature

providing a strong rationale for their combined use in the clinic

SD70 - Histone Demethylase JMJD2 Inhibitor. CAS# 332173-89-4 6057 InChiKey: ZKXZLIFRWWKZRY-KRWDZBQOSA-NSD70, CAS No. 332173 89 4, is a potent, selective and cell permeable inhibitor of histone demethylase JMJD2 (KDM4C), identified by phenotypic screening for inhibitors of ligand and genotoxic stress induced translocations in prostate cancer cells. Through Chem seq approach, SD70 was found to inhibit the androgen dependent AR program and prostate cancer cell growth, acting, at least in part, by functionally inhibiting the Jumonji domain containing