CEP-32496 nhibitor (racemic) Epub 2013 Sep 16
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CEP-32496 nhibitor (racemic) Epub 2013 Sep 16Agerafenib, also known as RXDX 105, CEP 32496 and AC013773, is an orally available v raf murine sarcoma viral oncogene homolog B1 (B raf) serine threonine protein kinase inhibitor with potential antineoplastic activity. CEP 32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B raf kinase. This inhibits the activation of the RAF mitogen activated protein kinase kinase (MEK) extracellular signal related kinase (ERK)
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