LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 Catalog No.:M60008-10S including both SET-domain-containing and non-SET

including both SET-domain-containing and non-SET domain-containing methyltransferases

It has >100-fold selectivity over a broad panel of 230 kinases

It inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo

(2012) PCT WO 2012009678

also known as Luminespib

LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 Catalog No.:M60008-10S including both SET-domain-containing and non-SETLDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal