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Pyruvate, -ketoglutarate, glutamate, and aspartate all stayed constant between the two groups (Figure 1)

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however, endogenous GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) to GLP-1(936) which has a weak binding affinity to GLP-1R and was previously presumed to have no biological effects ( Figure 6 , treatment with exendin-4 (GLP-1R agonist) remarkably attenuated MG-induced the elevation of both intracellular and mitochondrial ROS levels, which had effects similar to those of GLP-1(936) ( Figures 6A, B , respectively)