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A 2025 study involving Bifidobacterium strains demonstrated that probiotic-driven tryptophan metabolism produces indole derivatives that activate aryl hydrocarbon receptors (AhR), further upregulating proglucagon gene expression and GLP-1 synthesis (438)

For example, someone beginning treatment at 250 pounds may lose significantly more total pounds than someone starting at 180 pounds, even if both lose a similar percentage of body weight

Takahashi H, Nomiyama T, Terawaki Y, Kawanami T, Hamaguchi Y, Tanaka T, Tanabe M, Bruemmer D, Yanase T

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The study included: 67,769 people with type 2 diabetes and 17,604 people with overweight or obesity and cardiovascular disease but without diabetes