GSK2578215A - CAS# 1285515-21-0 ptan CAS Number: 1408064-71-0

CAS Number: 1408064-71-0

PubMed Central PMCID: PMC3754927

bisindolylmaleimide I(GF-109203X )inhibits PKC isozymes alpha

Chemical Name: 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4

1H-Imidazol-2-amine

GSK2578215A - CAS# 1285515-21-0 ptan CAS Number: 1408064-71-0GSK2578215A is a potent and highly selective LRRK2 kinase inhibitor. GSK2578215A induces protective autophagy in SH SY5Y cells: involvement of Drp 1 mediated mitochondrial fission and mitochondrial derived ROS signaling. Mutations in the leucine rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson's disease, and its inhibition opens potential new therapeutic options. GSK2578215A induces mitochondrial fragmentation of an early step