WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 Smiles: C[C@H](NC(=O)CCC1NC(=O)C2=CC=CC=C2N=1)C1C=CC=CC=1

Smiles: C[C@H](NC(=O)CCC1NC(=O)C2=CC=CC=C2N=1)C1C=CC=CC=1

It inhibits Wee1 in H3K36me3-deficient cells results in RRM2 reduction

GNF-2 interfered with actin cytoskeletal organization and subsequently blocked the bone-resorbing activity of mature osteoclasts

83797-69-7

Formula: C21H17NO3S2

WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 Smiles: C[C@H](NC(=O)CCC1NC(=O)C2=CC=CC=C2N=1)C1C=CC=CC=1WWL113, CAS No. 947669 86 5, is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0. 1 M in cellular assays. WWL113 was discovered by a high throughput screen. Carboxylesterase 3 (Ces3, also known as Ces1d) plays a key role in lipid metabolism (e. g., hydrolyzing long chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes. Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two