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Melasma develops due to several factors: Hormonal changes (pregnancy, oral contraceptives) Genetic predisposition Skin inflammation or irritation Certain medications Cosmetic products Heat and UV exposure Excessive sun exposure Sun exposure remains the strongest trigger , making sunscreen essential in treatment

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Targeted genetic silencing of SREBP2 in DCs, as well as its pharmacologic inhibition, enhanced antitumor CD8 + T cell activation and inhibited melanoma progression

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