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RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase an orally bioavailable selective inhibitor

RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase an orally bioavailable selective inhibitor

Name: RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase an orally bioavailable selective inhibitor
Brand: avramcheva.com
SKU: 80119126519
Price: 35.00 USD
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SKU: 80119126519

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RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase an orally bioavailable selective inhibitorRG108, CAS No. 48208 26 0, is a potent, selective and cell permeable inhibitor of DNA methyltransferase. Unlike 5 azaC, RG108 is not a nucleoside and therefore does not modify DNA. It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM. It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Treatment with RG108 results in the demethylation of genomic DNA and can reactivate

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Description

an orally bioavailable selective inhibitor of protein kinase CK2

Smiles: CC1(C)CC(C2C=CC(Cl)=CC=2)=C(CN2CCN(CC2)C2=CC(OC3C=C4C=CNC4=NC=3)=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(C=C2)NCC2CCOCC2)[N+]([O-])=O)CC1

70(22):9265-76

BMC Cancer

49(1):7-13

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