JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 acting as an antagonist of

acting as an antagonist of Smoothened

Katayama R

indicating that cycling populations of normal cells induce Chk1 pS345 following exposure to MK-8776 S-isomer as part of a futile cycle

thus attenuating phosphorylation of the Aurora substrate H3S10

Compared with control (vehicle-treated) tumors

JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 acting as an antagonist ofJNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a