AS2034178 - GPR40 Agonist. CAS# 1030846-42-4 size:2 mg solid 1616391-65-1

1616391-65-1

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor

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CUDC-907 was orally dosed to mice at 100 mg/kg or intravenously dosed at 50 mg/kg once per day in the xenograft tumor model of SU-DHL4 (DLBCL) and A549 (NSCLC)

AS2034178 - GPR40 Agonist. CAS# 1030846-42-4 size:2 mg solid 1616391-65-1AS2034178, CAS No. 1030846 42 4, is the potent, selective and orally bioavailable GPR40 (FFA1) agonist. It has good selectivity for over GPR41, GPR43, GPR119, GPR120 and PPAR. It can Induce glucose dependent insulin secretion in pancreatic MIN6 cells and in vivo. AS2034178 could decrease plasma glucose and HbA1c levels after repeat administration to ob ob mice, with favorable oral absorption and pharmacokinetics. Repeat administration of AS2034178