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Kartogenin (KGN) - Chondrogenesis Modulator. CAS# 4727-31-5 60434 produced by cytochrome P450 isoforms

Kartogenin (KGN) - Chondrogenesis Modulator. CAS# 4727-31-5 60434 produced by cytochrome P450 isoforms

Name: Kartogenin (KGN) - Chondrogenesis Modulator. CAS# 4727-31-5 60434 produced by cytochrome P450 isoforms
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Kartogenin (KGN) - Chondrogenesis Modulator. CAS# 4727-31-5 60434 produced by cytochrome P450 isoformsKartogenin (KGN), CAS No. 4727 31 5, is a potent small molecule that can promote chondrocyte differentiation of human mesenchymal stem cells MSCs (EC50 = 100 nM). It was identified by an imaging based high throughput screening in human MSCs. KGN also shows chondro protective effects in vitro, and is efficacious in collagenase and surgery induced OA models in mice. MOA studies suggested that KGN binds to filamin A, disrupts its interaction with the

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Description

produced by cytochrome P450 isoforms in the liver

(2014) Nat Commun

It also inhibits PLK2 and PLK3 with IC50 of 3

PubMed PMID: 22284361

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

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