Sephin1 Carbonate - PPP1R15A Protein Phosphatase Inhibitor. CAS# 951441-04-6 60432 9)10/h2-16H

9)10/h2-16H

acting via the HIF-1α system

5 μM in UM-UC-14

G-749 appears to be a promising next-generation drug candidate for the treatment of relapsed and refractory AML patients with various FLT3-ITD/FLT3-TKD mutants and further shows the ability to overcome drug resistance (Blood

selective and orally bioavailable Wee1 kinase inhibitor with IC50 of 5

Sephin1 Carbonate - PPP1R15A Protein Phosphatase Inhibitor. CAS# 951441-04-6 60432 9)10/h2-16HSephin1 Carbonate, CAS No. 951441 04 6, is a selective inhibitor of a holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. Sephin1 selectively bound and inhibited the stress induced PPP1R15A, but not the related and constitutive PPP1R15B, to prolong the benefit of an adaptive phospho signaling pathway, protecting cells from otherwise lethal protein misfolding stress. In vivo, Sephin1 safely