Clofarabine nine TG100-115 inhibits PI3Kγ and PI3Kδ

TG100-115 inhibits PI3Kγ and PI3Kδ with IC50s of 83 and 235 nM

and downstream effectors

InChiKey: OVDSPTSBIQCAIN-UHFFFAOYSA-N

is an inverse agonist at the human cannabinoid CB1 receptor

NP-118809 is a N-type calcium channel blocker

Clofarabine nine TG100-115 inhibits PI3Kγ and PI3KδClofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5' triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of