Gamabufotalin Catalog No.:M8396-2 33)/t16-/m0/s1
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Gamabufotalin Catalog No.:M8396-2 33)/t16-/m0/s1Gamabufotalin (Gamabufagin), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. IC50 value: Target: in vitro: Gamabufotalin (CS 6) strongly suppressed COX 2 expression by inhibiting the phosphorylation of IKK via targeting the ATP binding site, thereby abrogating NF B binding and p300 recruitment to COX 2 promoter. In addition, CS 6 induced apoptosis by activating the
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