ARCC 4 - a PROTAC. CAS# 1973403-00-7 60015 1–10 μM)
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ARCC 4 - a PROTAC. CAS# 1973403-00-7 60015 1–10 μM)ARCC 4, CAS No. 1973403 00 7, is a PROTAC, acting as an androgen receptor degrader. ARCC 4 is a low nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC 4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC 4 exemplifies how protein degradation can
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