Zatebradine Catalog No.:M8447-2 Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB

Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB activation

Chemical Name: 2-(4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl)-1-(1H-1

PubMed PMID: 26185454

It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1)

N'-{[(5-methoxy-1H-indol-3-yl)methylidene]amino}-N-pentylguanidine

Zatebradine Catalog No.:M8447-2 Nafamostat mesilate inhibits gemcitabine-induced NF-kappaBZatebradine (UL FS 49 (free base); UL FS 49CL (free base)) is a potent inhibitor of hyperpolarization activated cyclic nucleotide gated (HCN) channels with an IC50 value of 1. 96 M. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1. 83 M, 2. 21 M, 1. 90 M and 1. 88 M, respectively. Product information CAS Number: 85175 67 3 Molecular Weight: 456. 57 Formula: C26H36N2O5 Synonym: UL FS49