AGN 194310 I-3 appears to have the potential
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AGN 194310 I-3 appears to have the potentialAGN 194310, also known as VTP 194310, is a pan antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR , RAR and RAR, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR , RAR and RAR, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+ grown cell lines with IC50 values of 16
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