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GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24

GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24

Name: GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24
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SKU: 90129285943
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GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24GSK2879552 dihydrochloride, CAS No. 1902123 72 1, is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO A B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions

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K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24

2007 May 1

12(8):1442-52

It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM)

and decrease markers of DNA damage in these cells

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