ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid InChiKey: FWWMRDPEXYCBRS-UHFFFAOYSA-N

InChiKey: FWWMRDPEXYCBRS-UHFFFAOYSA-N

Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases

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Smiles: CCCCC1=NC(Cl)=C(C(O)=O)N1CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1

Lactate-sulfate grown cells are insensitive to the Na+ ionophore

ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid InChiKey: FWWMRDPEXYCBRS-UHFFFAOYSA-NABT 199, CAS No. 1257044 40 8, is a highly potent, selective, and orally bioavailable BCL 2 inhibitor. ABT 199 has picomolar affinity for BCL 2 (Ki < 0. 010 nM) and > 1000 folds selectivity over BCL XL (Ki = 48 nM) and BCL W (Ki = 245 nM). Therefore, ABT 199 is a much improved lead compound over the original ABT 263 (navitoclax) to avoid thrombocytopenia caused by BCL XL inhibition. ABT 199s cell killing effect is selective and mechanism dependent. It