SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 120 4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5

4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5

CAS Number: 1431280-51-1

doses of MK-8776 S-isomer associate with robust biomarker activation and improved tumor response are not associated with enhanced toxicity of gemcitabine on hematological parameters in BALB/c mice

Abastabar M

Neudörfl JM

SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 120 4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5SR9011, CAS No. 1379686 29 9, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~790 nM and REV ERB with EC50 ~560 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock