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These adaptations emphasize that IGF-1 therapy cannot follow a universal protocol, but rather requires multidimensional optimization based on individual patient profiles and injury context

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The effect of semaglutide compared to placebo on estimated GFR was calculated using a MMRM model with two-sided P-values and with fixed effects for treatment, visit, baseline log-transformed UACR, the interaction between treatment and visit, and the interaction between baseline and estimated GFR