CAL-130 - CAS# 1431697-74-3 Size:Solid 10 mg 5(4):355-7

5(4):355-7

Neurite outgrowth induced by expression of the mALKR1279Q mutant is completely inhibited at 30 nM NVP-TAE684

CAS Number: 63302-99-8

BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas

whereas only slight activation is observed in the absence of either of them or when the enzyme is heat inactivated

CAL-130 - CAS# 1431697-74-3 Size:Solid 10 mg 5(4):355-7CAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support