Chidamide 0066 10(13):4559-67

10(13):4559-67

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation

Formula: C22H23ClN2O8

Theodoulou NH

PubMed PMID: 22806357

Chidamide 0066 10(13):4559-67Tucidinostat (also known as HBI 8000, Chidamide, and CS 055) is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Tucidinostat selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K Akt and MAPK Ras signaling pathways and may result in cell cycle arrest