ARRY-520 (R) 30002 Devereux S

Devereux S

Tissue distribution of BLU-554 (10 mg/kg

ZSTK474 blocks VEGF-induced cell migration and the tube formation in human umbilical vein endothelial cells (HUVECs)

Absorption is relatively rapid in dogs but slower in mice (10 mg/kg)

306(5705):2257-60

ARRY-520 (R) 30002 Devereux SARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product