KPT-330 - CAS# 1393477-72-9 Catalog No.:M6605-10 and the extensive internalization was

and the extensive internalization was observed at 200 μm 6-OAU stimulation

Epub 2011 Jun 13

Formula: C31H31NO3

Ba/F3 cells harboring native or T315I mutated Bcr-Abl constructs were treated with GNF-2 and AKIs

[O-]C(=O)CCN1C(=O)/C(=C/C2=CC=C(O2)C2C=CC(=CC=2)[N+]([O-])=O)/SC1=S

KPT-330 - CAS# 1393477-72-9 Catalog No.:M6605-10 and the extensive internalization wasKPT 330, CAS No. 1393477 72 9, is an orally bioavailable, potent and selective XPO1 CRM1 Inhibitor. KPT 330 is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. KPT 330 potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth, depletion of the antiapoptotic proteins, and induction of apoptosis. KPT 330 has strong activity against primary