CYC-116 0-IN-1 612847-09-3

612847-09-3

SAR439859 shows promising antitumor activity in breast cancer mice xenograft models

7 cells on calcium phosphate-coated plates

27(1):47-56

InChiKey: BJPJNTKRKALCPP-UHFFFAOYSA-N

CYC-116 0-IN-1 612847-09-3CYC116 is an orally bioavailable small molecule multi kinase inhibitor with antineoplastic activity. Aurora kinase VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine threonine protein kinases that are only expressed in actively dividing cells and are critical in