Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 TAS4464 treatment inhibits cullin neddylation

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1

Metformin increases ATM and AMPK phosphorylation

In vitro cytotoxicity and in vivo efficacy

3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9

Sinclair KD

Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 TAS4464 treatment inhibits cullin neddylationNutlin 3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin 3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Product information CAS Number: 548472 68 0 Molecular Weight: 581. 49 Formula: C30H30Cl2N4O4 Synonym: () Nutlin 3 Nutlin 3 Related CAS Number: