OSI-906 Size:10mg solid PubMed PMID: 17889719

PubMed PMID: 17889719

Romidepsin

Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

InChi: InChI=1S/C42H70O11

A significant increase of the animal lifespan in the test groups (from 4

OSI-906 Size:10mg solid PubMed PMID: 17889719OSI 906, is a n orally bioavailable small molecule inhibitor of the insulin like growth factor 1 receptor (IGF 1R) with potential antineoplastic activity. OSI 906 selectively inhibits IGF 1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR 1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis. Product