DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid CAS Number: 847925-91-1

CAS Number: 847925-91-1

which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells

2007 May 1

InChi: InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7

CAS Number: 1351758-81-0

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid CAS Number: 847925-91-1DASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent