ETC-159 - CAS# 1638250-96-0 size:2mg solid Epub 2013 Sep 16

Epub 2013 Sep 16

Kenpaullone demonstrates a wide range of biological utility

In PC3 xenograft model

15(1):23-36

collagen content is quantified in the lungs to evaluate the anti-fibrotic effects of Pirfenidone

ETC-159 - CAS# 1638250-96-0 size:2mg solid Epub 2013 Sep 16ETC 159, CAS No. 1638250 96 0, also known as ETC 1922159, is a potent, selective and orally available PORCN inhibitor. ETC 159 blocks the secretion and activity of all Wnts. ETC 159 is remarkably effective in treating RSPO translocation bearing colorectal cancer (CRC) patient derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is