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2021;384(11):989-1002 (STEP 1)

If an unopened pen has been kept at room temperature beyond the specific time allowed in its product information, or if an in-use multi-dose pen has exceeded its room temperature storage period, contact your pharmacist or diabetes specialist nurse for advice

The distal end (S49 ECD ) of the helix was more mobile than the proximal one (E34 ECD ), which had an overall tendency to remain in the proximity of the TT-OAD2-binding site, driven by transient interactions with the ligand (Extended Data Table 1) and hydrogen bonds with the R299 ECL2 side chain (Extended Data Table 2)

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