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14 Recommendations The results above have prompted the ADA and EASD to recommend GLP-1RAs as preferred second- or third-line injectable agents following metformin in people with: 1 established atherosclerotic cardiovascular disease a need to minimise weight gain or promote weight loss a need to minimise hypoglycaemia mild-to-moderate chronic kidney disease

This slows how fast the stomach empties, increases satiety, and helps regulate nutrient absorption for improved metabolic health

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Saccharomyces boulardii may help diarrhoea whilst Bifidobacterium lactis strains may improve constipation

Insufficient Clinical Data: Clinical trials for Ozempic routinely exclude breastfeeding women, meaning robust data on how the medication might affect infant development, metabolism, or pancreatic health over time simply doesn't exist