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Who benefits most from L-Carnitine L-carnitine and weight loss supplementation may be particularly useful for: Individuals training 3 to 5 times per week Those in a structured calorie deficit Endurance athletes People seeking performance support during cutting phases It may be less noticeable for sedentary individuals or those expecting immediate, dramatic fat loss without lifestyle adjustments

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The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)

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