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Retatrutide belongs to a class of peptide-based therapies that target hormones involved in appetite regulation and metabolism

b , Structure comparison of SLC33A1 in the presence of GSSG or acetyl-CoA shows partial overlap in residues proximal to the bound ligands, including Y225 and Y418

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Investigators reported that gastrointestinal effects were the most common adverse events, were generally mild to moderate, and usually occurred during the dose-escalation phase of the study