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Side effects, mostly gastrointestinal issues, led between 5% and 10% of participants in the orforglipron study to discontinue treatment, compared with nearly 3% in the placebo group

nearly doubles muscle fiber cross-sectional area and increases muscle contractile strength by ~70%, restoring regenerative function to levels comparable to youthful muscle 1

doi: 10.1002/jsfa.4597

The compound is not listed as a scheduled controlled substance under the international drug-control conventions or under the major national scheduling systems