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Safety Profile and Tolerability Concerns Gastrointestinal Adverse Effects While GLP-1RAs are effective in managing obesity, their use is associated with gastrointestinal side effects and rare but serious adverse events [42] [43] [44]

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The trial findings suggest that individuals may have greater flexibility in how they continue treatment after achieving substantial weight loss

Patients with pre-existing cardiac conditions , particularly those with heart failure or significant arrhythmias, should be monitored appropriately when initiating GLP-1 receptor agonist therapy