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GLP-1 medications like Mounjaro, Wegovy and Ozempic have become a popular tool for weight management, with an estimated 1.6 million people using them in Great Britain alone.[1] While these medications can be highly effective for supporting weight loss, theres evidence that weight regain is common after treatment stops.[2] This is because GLP-1 medications work by reducing appetite and supporting metabolic processes that make it easier to lose weight

Conversely, other research reveals that sustained low ROS levels may enhance M2 macrophage polarization without significantly affecting M1 macrophages ( 2 O 2 (Wang et al., 2022), LPS (Yan et al., 2020), ferric ammonium citrate (FAC) (Yang et al., 2023)

These ratios in exposed rats were 8.3% - 33% for semaglutide, 9.4% for lixisenatide and 50% for liraglutide

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