TSSP Rabbit Polyclonal Antibody, 100ul Yeast Expression SIM1 and SIM2 genes are

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs

The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium

Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains

Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein| and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1

TSSP Rabbit Polyclonal Antibody, 100ul Yeast Expression SIM1 and SIM2 genes areThis gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6 near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described but its full length nature has not been