TACE Polyclonal Antibody, 100ul Electrophoresis & Labeling Two main isozymes are known

Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm

Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes

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Alternative splicing results in several additional transcript variants| some encoding different isoforms and others that have not been fully characterized

There are pseudogenes for this gene on chromosomes 2 and 17

TACE Polyclonal Antibody, 100ul Electrophoresis & Labeling Two main isozymes are knownADAM17 (ADAM metallopeptidase domain 17) encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell cell and cell matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to